Ho hlokahala li-buffer tse ngata ts'ebetsong ea tlhoekiso ea noka ea biopharmaceuticals. Ho nepahala le ho ikatisa ha li-buffer ho na le tšusumetso e kholo ts'ebetsong ea tlhoekiso ea protheine. Sistimi ea ho hlapolla le ea marang-rang e ka kopanya mefuta e fapaneng ea li-buffer tsa karolo e le 'ngoe. Joala ba 'm'e le bo hlapollang bo tsoakoa marang-rang ho fumana tharollo e nepahetseng. Sehlahisoa se ipapisitse le tsebo ea mahlale, 'me boleng bo tsoa mohopolong oa moralo (QbD). Ka nako ea 'nete ea marang-rang (Real in time) ho lekola le ho laola matšoao a mabeli a lik'hemik'hale, lintlha tsa bohlokoa tsa boleng (CQA) tsa sehlahisoa (CQA), pH le conductivity nakong ea ts'ebetso ea tlhahiso, Etsa bonnete ba ho fana ka li-buffers tse tsitsitseng le tse sa tšoaneng. boleng bakeng sa lits'ebetso tse tlase ho thusa merero ea tokollo ea lik'hamphani tsa biopharmaceutical. Mokhoa o tloaelehileng oa ho lokisa mokelikeli o hloka palo e kholo ea litanka le molumo o moholo. IVEN e tlisetsa bareki boiphihlelo bo bocha ba tekheniki, e fokotsang sebaka sa "buffer dosing" sethaleng sa ts'ebetso ea tlhoekiso, le ho fokotsa litšenyehelo tsa pele ho matsete le kamora tlhahiso le ts'ebetso. , Ntlafatsa katleho ea tlhahiso, etsa bonnete ba hore li-parameter tsa bohlokoa tsa ts'ebetso (CPP) ea buffer le traceability ea eona, 'me qetellong e ntlafatsa boleng ba meriana.