Tlhaloso ea Sehlahisoa:

Ho hlokahala li-buffer tse ngata ts'ebetsong ea tlhoekiso ea noka ea biopharmaceuticals.Ho nepahala le ho ikatisa ha li-buffer ho na le tšusumetso e kholo ts'ebetsong ea tlhoekiso ea protheine.Sistimi ea ho hlapolla le ea marang-rang e ka kopanya mefuta e fapaneng ea li-buffer tsa karolo e le 'ngoe.Joala ba 'm'e le bo hlapollang bo tsoakoa marang-rang ho fumana tharollo e nepahetseng.Sehlahisoa se ipapisitse le tsebo ea mahlale, 'me boleng bo tsoa mohopolong oa moralo (QbD).Ka nako ea 'nete ea marang-rang (Real in time) ho lekola le ho laola matšoao a mabeli a lik'hemik'hale, lintlha tsa bohlokoa tsa boleng (CQA) tsa sehlahisoa (CQA), pH le conductivity nakong ea ts'ebetso ea tlhahiso, Etsa bonnete ba ho fana ka li-buffers tse tsitsitseng le tse sa tšoaneng. boleng bakeng sa lits'ebetso tse tlase ho thusa merero ea tokollo ea lik'hamphani tsa biopharmaceutical.Mokhoa o tloaelehileng oa ho lokisa mokelikeli o hloka palo e kholo ea litanka le molumo o moholo.IVEN e tlisetsa bareki boiphihlelo bo bocha ba tekheniki, e fokotsang sebaka sa "buffer dosing" sethaleng sa ts'ebetso ea tlhoekiso, le ho fokotsa litšenyehelo tsa pele ho matsete le kamora tlhahiso le ts'ebetso., Ntlafatsa katleho ea tlhahiso, etsa bonnete ba hore li-parameter tsa bohlokoa tsa ts'ebetso (CPP) ea buffer le traceability ea eona, 'me qetellong e ntlafatsa boleng ba meriana.