Lefapheng la biotechnology le biopharmaceutical, mantsoe "bioreactor" le "biofermenter" hangata a sebelisoa ka ho fapanyetsana, empa a bua ka litsamaiso tse fapaneng tse nang le mesebetsi le ts'ebeliso e itseng. Ho utloisisa phapang pakeng tsa mefuta ena e 'meli ea thepa ke ea bohlokoa bakeng sa litsebi tšimong, haholo-holo ha ho qaptjoa le ho etsa litsamaiso tse finyellang litekanyetso tse thata tsa taolo.

Ho hlalosa Melao

Bioreactor ke lentsoe le pharaletseng le koahelang setshelo leha e le sefe seo karabelo ea tlhaho e hlahang ho sona. Sena se ka kenyelletsa lits'ebetso tse fapaneng joalo ka ho belisoa, setso sa lisele, le karabelo ea li-enzyme. Li-bioreactors li ka etsoa bakeng sa maemo a aerobic kapa anaerobic 'me li ka tšehetsa mefuta e mengata ea lintho tse phelang, ho kenyeletsoa libaktheria, tomoso le lisele tsa mammalian. Li na le mefuta e fapaneng ea mocheso, pH, boemo ba oksijene le taolo ea tsitsipano ho ntlafatsa maemo a kholo bakeng sa likokoana-hloko kapa lisele tse holileng.

Ka lehlakoreng le leng, biofermenter ke mofuta o ikhethileng oa bioreactor o sebelisoang haholo lits'ebetsong tsa ho belisoa. Ho belisoa ke ts'ebetso ea metabolism e sebelisang likokoana-hloko, hangata tomoso kapa baktheria, ho fetola tsoekere hore e be acid, likhase kapa joala.Li-biofermenters li etselitsoe ho theha tikoloho e loketseng kholo ea likokoana-hloko tsena, ka hona ho hlahisa mefuta e fapaneng ea bioproducts tse kang ethanol, organic acids, le meriana.

Liphapang tse ka Sehloohong

Mosebetsi:

Li-bioreactors li ka sebelisoa bakeng sa mefuta e fapaneng ea li-bioprocesses, ho kenyeletsoa setso sa lisele le karabelo ea enzyme, athe fermenters e etselitsoe lits'ebetso tsa ho belisoa.

Litlhaloso tsa Moqapi:
Li-biofermentershangata li entsoe ka likarolo tse itseng ho khotsofatsa litlhoko tsa lintho tse phelang tse lomosang. Ka mohlala, li ka kenyelletsa likarolo tse kang li-baffles ho ntlafatsa ho kopanya, mekhoa e khethehileng ea aeration bakeng sa ho belisoa ha aerobic, le mekhoa ea ho laola mocheso ho boloka maemo a ho hōla a nepahetseng.

Kopo:
Li-bioreactors li sebetsa ka mokhoa o fapaneng haholo 'me li ka sebelisoa bakeng sa lits'ebetso tse fapaneng liindastering tse fapaneng, ho kenyeletsoa meriana, lijo le lino, le biotechnology ea tikoloho. Ka lehlakoreng le leng, li-fermenters li sebelisoa haholo-holo liindastering tse hlahisang lihlahisoa tsa ho belisoa, tse kang ho etsa veine, ho ritela le ho hlahisa biofuel.

Sekala:
Ka bobeli li-bioreactors le fermenters li ka etsoa ho ea ka sekala se fapaneng, ho tloha lipatlisisong tsa laboratori ho isa tlhahisong ea indasteri. Leha ho le joalo, li-fermenters hangata li na le bokhoni bo boholo ba ho amohela bongata bo boholo ba sehlahisoa se hlahisoang ka tloaelo nakong ea ho belisoa.

Karolo ea GMP le ASME-BPE moralong oa fermenter

Ho ikamahanya le maemo a taolo ho bohlokoa ha ho tluoa ho moralo le tlhahiso eali-bio-fermenters. Ho IVEN, re etsa bonnete ba hore fermenters ea rona e entsoe le ho etsoa ka tumellano e tiileng le melaoana ea Good Manufacturing Practice (GMP) le litlhoko tsa ASME-BPE (American Society of Mechanical Engineers - Bioprocessing Equipment). Boitlamo bona ba boleng le polokeho bo bohlokoa ho bareki ba rona ba biopharmaceutical ba itšetlehileng ka lisebelisoa tsa rona bakeng sa ho belisa setso sa likokoana-hloko.

Tsa ronalitanka tse belisoange na le meralo ea profeshenale, e bonolo ho mosebedisi le ea modular e ka kopanngoang habonolo le lits'ebetsong tse teng. Re fana ka likepe tse lumellanang le maemo a fapaneng a likepe tsa khatello ea naha, ho kenyelletsa ASME-U, GB150 le PED (Pressure Equipment Directive). Ts'ebetso ena e fapaneng e netefatsa hore litanka tsa rona li ka amohela mefuta e mengata ea likopo le litlhoko tsa taolo.

Customization le Versatility

Ho VEN, rea utloisisa hore moreki e mong le e mong oa biopharmaceutical o na le litlhoko tse ikhethang. Ke ka lebaka leo re fanang ka mefuta e felletseng ea li-fermenters bakeng sa temo ea likokoana-hloko, ho tloha laboratoring ea R&D ho isa tlhahisong ea liteko le indastering. Li-fermenters tsa rona li ka etsoa ho latela litlhoko tse itseng, ho kenyelletsa le bokhoni, ho tloha ho lilithara tse 5 ho isa ho tse 30. Ho feto-fetoha ha maemo hona ho re lumella ho finyella litlhoko tsa libaktheria tse matla haholo, tse kang Escherichia coli le Pichia pastoris, tse atisang ho sebelisoa tlhahiso ea biopharmaceutical.

Ka kakaretso, ha ka bobeli bioreactors leli-biofermentersli bapala karolo ea bohlokoa lefapheng la theknoloji ea baeloji, li sebelisetsoa merero e fapaneng 'me li entsoe ho nahanoa ka mesebetsi e fapaneng. Ho utloisisa phapang ena ho bohlokoa ho khetha lisebelisoa tse nepahetseng bakeng sa ts'ebeliso e itseng. Ho IVEN, re ikemiselitse ho fana ka li-fermenters tsa boleng bo holimo tse fihlelang litlhoko tse thata tsa indasteri ea biopharmaceutical, ho netefatsa hore bareki ba rona ba ka fumana litholoana tse ntle ka ho fetisisa lits'ebetsong tsa bona tsa temo ea likokoana-hloko. Hore na o mothating oa ho etsa lipatlisiso kapa o eketsa tlhahiso ea indasteri, boitseanape ba rona le litharollo tseo u ka li khethang li ka u thusa ho bona mathata a bioprocessing ka boitšepo.