Mafapheng a theknoloji ea baeloji le meriana ea bio, mantsoe "bioreactor" le "biofermenter" hangata a sebelisoa ka ho fapanyetsana, empa a bua ka litsamaiso tse fapaneng tse nang le mesebetsi le lits'ebetso tse itseng. Ho utloisisa liphapang lipakeng tsa mefuta ena e 'meli ea lisebelisoa ho bohlokoa bakeng sa litsebi lefapheng lena, haholo-holo ha ho etsoa litsamaiso tse fihlelang litekanyetso tse thata tsa taolo.

Ho Hlalosa Mantsoe

Bioreactor ke lentsoe le pharaletseng le akaretsang setshelo sefe kapa sefe seo karabelo ea baeloji e etsahalang ho sona. Sena se ka kenyelletsa lits'ebetso tse fapaneng joalo ka ho belisa, setso sa sele, le liketso tsa enzyme. Bioreactors e ka etsoa bakeng sa maemo a aerobic kapa a anaerobic mme e ka tšehetsa mefuta e mengata ea lintho tse phelang, ho kenyeletsoa libaktheria, tomoso le lisele tsa liphoofolo tse anyesang. Li hlomelloa ka mefuta e fapaneng ea mocheso, pH, boemo ba oksijene, le taolo ea ho sisinyeha ho ntlafatsa maemo a kholo bakeng sa likokoana-hloko kapa lisele tse lengoang.

Ka lehlakoreng le leng, biofermenter ke mofuta o itseng oa bioreactor o sebelisoang haholo-holo lits'ebetsong tsa ho belisa. Ho belisa ke ts'ebetso ea metabolism e sebelisang likokoana-hloko, hangata tomoso kapa libaktheria, ho fetola tsoekere hore e be li-acid, likhase kapa joala.Li-biofermenters di etseditswe ho theha tikoloho e thusang kgolo ya dikokwana-hloko tsena, ka hona di hlahisa mefuta e fapaneng ya dihlahiswa tsa tlhaho tse kang ethanol, di-acid tsa organic le meriana.

Liphapang tse ka Sehloohong

Mosebetsi:

Li-bioreactor li ka sebelisoa bakeng sa mefuta e fapaneng ea lits'ebetso tsa bio, ho kenyeletsoa le setso sa sele le liketso tsa enzyme, ha li-fermenters li etselitsoe ka ho khetheha lits'ebetso tsa ho belisa.

Litlhaloso tsa Moralo:
Li-biofermentersHangata di entswe ka dikarolo tse ikgethang ho fihlela ditlhoko tsa diphedi tse bedisang. Mohlala, di ka kenyeletsa dikarolo tse kang di-baffle ho ntlafatsa ho kopanya, ditsamaiso tse ikgethang tsa moya bakeng sa ho bedisa aerobic, le ditsamaiso tsa taolo ya mocheso ho boloka maemo a matle a kgolo.

Kopo:
Li-bioreactor li na le mekhoa e mengata haholo 'me li ka sebelisoa bakeng sa lits'ebetso tse fapaneng liindastering tse fapaneng, ho kenyeletsoa meriana, lijo le lino, le theknoloji ea baeloji ea tikoloho. Ka lehlakoreng le leng, li-fermenters li sebelisoa haholo-holo liindastering tse hlahisang lihlahisoa tsa ho belisa, tse kang ho etsa veine, ho ritela le tlhahiso ea biofuel.

Sekala:
Li-bioreactor le li-fermenter ka bobeli li ka etsoa ka litekanyo tse fapaneng, ho tloha lipatlisisong tsa laboratori ho ea tlhahisong ea indasteri. Leha ho le joalo, hangata li-fermenter li na le bokhoni bo boholo ba ho amohela bongata ba lihlahisoa tse hlahisoang hangata nakong ea ts'ebetso ea ho belisa.

Karolo ea GMP le ASME-BPE moralong oa fermenter

Ho latela maemo a taolo ho bohlokwa ha ho tluwa tabeng ya moralo le tlhahiso yali-bio-fermentersHo IVEN, re netefatsa hore di-fermenters tsa rona di entswe mme di etswa ho latela ka botlalo melaoana ya Good Manufacturing Practice (GMP) le ditlhoko tsa ASME-BPE (American Society of Mechanical Engineers - Bioprocessing Equipment). Boitlamo bona ba boleng le polokeho bo bohlokwa ho bareki ba rona ba biopharmaceutical ba itshetlehileng ka disebediswa tsa rona bakeng sa ho bedisa setso sa dikokwana-hloko.

Ea ronalitanka tsa belisoae na le meralo ea profeshenale, e bonolo ho e sebelisa le ea modular e ka kopanngoang habonolo lits'ebetsong tse seng li ntse li le teng. Re fana ka likepe tse lumellanang le maemo a fapaneng a likepe tsa khatello ea naha, ho kenyeletsoa ASME-U, GB150 le PED (Pressure Equipment Directive). Ho feto-fetoha hona ho netefatsa hore litanka tsa rona li ka amohela mefuta e mengata ea lits'ebetso le litlhoko tsa taolo.

Ho iketsetsa le ho feto-fetoha ha lintho

Ho IVEN, re utloisisa hore moreki e mong le e mong oa meriana ea tlhaho o na le litlhoko tse ikhethang. Ke ka lebaka leo re fanang ka mefuta e felletseng ea li-fermenters bakeng sa temo ea likokoana-hloko, ho tloha ho R&D ea laboratori ho isa tlhahisong ea liteko le ea indasteri. Li-fermenters tsa rona li ka fetoloa ho latela litlhoko tse itseng, ho kenyeletsoa le bokhoni, ho tloha ho lilithara tse 5 ho isa ho lik'hilomithara tse 30. Ho tenyetseha hona ho re lumella ho fihlela litlhoko tsa libaktheria tse nang le aerobic e ngata, tse kang Escherichia coli le Pichia pastoris, tse sebelisoang hangata tlhahisong ea meriana ea tlhaho.

Ka bokhutšoanyane, ha li-bioreactor leli-biofermentersli bapala karolo ea bohlokoa lefapheng la theknoloji ea baeloji, li sebelisetsoa merero e fapaneng 'me li entsoe ka mesebetsi e fapaneng kelellong. Ho utloisisa liphapang tsena ho bohlokoa ho khetheng lisebelisoa tse nepahetseng bakeng sa ts'ebeliso e itseng. Ho IVEN, re ikemiselitse ho fana ka li-fermenters tsa boleng bo holimo tse fihlelang litlhoko tse thata tsa indasteri ea meriana ea baeloji, ho netefatsa hore bareki ba rona ba ka fihlela liphetho tse ntle ka ho fetisisa lits'ebetsong tsa bona tsa temo ea likokoana-hloko. Hore na u maemong a pele a lipatlisiso kapa u eketsa tlhahiso ea indasteri, boiphihlelo ba rona le litharollo tse ka fetoloang li ka u thusa ho sebetsana ka kholiseho le mathata a bioprocessing.